Rpl14 Gene Summary [Mouse]
A structural constituent of ribosome. Predicted to be involved in rRNA processing and ribosomal large subunit biogenesis. Located in cytoplasm. Part of cytosolic large ribosomal subunit. Is active in synapse. Is expressed in several structures, including central nervous system; neural retina; nucleus pulposus; pancreas epithelium; and ureter. Human ortholog(s) of this gene implicated in systemic lupus erythematosus. Orthologous to human RPL14 (ribosomal protein L14). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rpl14 |
| Official Name | ribosomal protein L14 [Source:MGI Symbol;Acc:MGI:1914365] |
| Ensembl ID | ENSMUSG00000025794 |
| Bio databases IDs | |
| Aliases | ribosomal protein L14 |
| Synonyms | 3100001N19RIK, 60S ribosomal protein L14, CAG-ISL-7, CTG-B33, eL14, hRL14, L14, ribosomal protein L14, RL14 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rpl14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of ribosome
- 6-pyruvoyl-tetrahydropterin synthase related domain (membrane protein)
- protein binding
- Vairimorpha necatrix ribosomal protein eL14 and similar proteins
- RNA binding
Pathways
Biological processes and signaling networks where the Rpl14 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- interchromatin granule cluster fractions
- pH resistant lipid raft fraction
- ribosome
- cytosol
- nucleoli
- synapse
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rpl14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoplasmic translation
- ribosomal large subunit biogenesis
- rRNA processing
- translation
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- extracellular vesicular exosome
- cytosolic ribosome
- cytoplasm
- membrane
- cytosol
- cytosolic large ribosomal subunit
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- structural constituent of ribosome
- cadherin binding