Lap3 Gene Summary [Mouse]
Enables peptidase activity. Predicted to be involved in proteolysis. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human LAP3 (leucine aminopeptidase 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lap3 |
| Official Name | leucine aminopeptidase 3 [Source:MGI Symbol;Acc:MGI:1914238] |
| Ensembl ID | ENSMUSG00000039682 |
| Bio databases IDs | |
| Aliases | leucine aminopeptidase 3 |
| Synonyms | 2410015L10Rik, HEL-S-106, LAP, LAPEP, Leucine aminopeptidase, leucine aminopeptidase 3, PEP7, PEPS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lap3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Peptidase_M17
- macrodomain superfamily
- peptidase
- protein binding
- Cytosol aminopeptidase family, N-terminal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- epithelial cancer
- breast cancer
- liver cancer
- androgenic alopecia
- hepatitis C virus-related hepatocellular carcinoma
- lichen planus
role in cell
- expression in
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
- trans Golgi network
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lap3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
Cellular Component
Where in the cell the gene product is active
- nucleus
- trans-Golgi network
- extracellular vesicular exosome
- focal adhesion
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- carboxypeptidase activity
- protein binding
- metalloaminopeptidase activity
- metalloexopeptidase activity
- manganese ion binding
- aminopeptidase activity
- peptidase activity