Dppa3 Gene Summary [Mouse]

Enables methylated histone binding activity. Involved in epigenetic programing of female pronucleus. Acts upstream of or within embryonic cleavage. Located in chromatin; cytoplasm; and pronucleus. Is expressed in several structures, including central nervous system; early conceptus; gonad; hindgut diverticulum; and primordial germ cell. Orthologous to human DPPA3 (developmental pluripotency associated 3). [provided by Alliance of Genome Resources, Apr 2025]

Details

Type
Protein Coding
Official Symbol
Dppa3
Official Name
developmental pluripotency-associated 3 [Source:MGI Symbol;Acc:MGI:1920958]
Ensembl ID
ENSMUSG00000046323
Bio databases IDs NCBI: 73708 Ensembl: ENSMUSG00000046323
Aliases developmental pluripotency-associated 3
Synonyms 2410075G02Rik, developmental pluripotency-associated 3, PCG7, PGC7, STELLA
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dppa3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • histone binding
  • PGC7/Stella/Dppa3 domain
  • protein binding activity, bridging
  • protein binding

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • borderline personality disorder
regulated by
role in cell
  • expression in
  • differentiation

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • Cytoplasm
  • cytosol
  • nucleoplasm
  • pronucleus
  • chromatin

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Dppa3 gene, providing context for its role in the cell.

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • male pronucleus
  • cytoplasm
  • female pronucleus

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • methylated histone residue binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.