Stmn2 Gene Summary [Mouse]
Predicted to enable calcium-dependent protein binding activity and tubulin binding activity. Predicted to be involved in several processes, including cellular response to nerve growth factor stimulus; regulation of microtubule polymerization or depolymerization; and regulation of neuron projection development. Located in growth cone. Is expressed in several structures, including alimentary system; autopod; genitourinary system; nervous system; and nose. Used to study amyotrophic lateral sclerosis; motor peripheral neuropathy; and neuropathy. Orthologous to human STMN2 (stathmin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Stmn2 |
| Official Name | stathmin-like 2 [Source:MGI Symbol;Acc:MGI:98241] |
| Ensembl ID | ENSMUSG00000027500 |
| Bio databases IDs | |
| Aliases | stathmin-like 2 |
| Synonyms | SCG10, SCGN10, stathmin 2, stathmin-like 2, Stmb2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Stmn2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium-dependent protein binding
- tubulin binding domain
- membrane attachment signal
- protein binding
- stathmin domain
- Stathmin family
Pathways
Biological processes and signaling networks where the Stmn2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pathological denervation
- schizophrenia
- motor dysfunction
- diabetic nephropathy
- androgenic alopecia
- Budd-Chiari syndrome
- squamous-cell carcinoma
- squamous cell cancer
- Down syndrome
- hemangioma
regulates
- tubulin
- guanosine triphosphate
- APP
role in cell
- production in
- formation
- quantity
- assembly
- outgrowth
- fragmentation
- development
- differentiation
- disruption
- polymerization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- Cytoplasm
- perinuclear region
- punctate structures
- vesicles
- Golgi Apparatus
- cytosol
- growth cone
- neurites
- nerve ending
- perikaryon
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Stmn2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron projection development
- negative regulation of neuron projection development
- negative regulation of microtubule depolymerization
- positive regulation of neuron projection development
- regulation of microtubule polymerization or depolymerization
- positive regulation of microtubule depolymerization
- microtubule depolymerization
- negative regulation of microtubule polymerization
Cellular Component
Where in the cell the gene product is active
- growth cone
- endosome
- perinuclear region of cytoplasm
- cytoplasm
- membrane
- cytosol
- Golgi apparatus
- neuronal cell body
- neuron projection
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- tubulin binding
- protein binding
- calcium-dependent protein binding