Ncoa7 Gene Summary [Mouse]
Predicted to enable nuclear receptor binding activity and transcription coactivator activity. Acts upstream of or within negative regulation of cellular response to oxidative stress and negative regulation of peptidyl-cysteine S-nitrosylation. Predicted to be active in nucleus. Is expressed in several structures, including adipose tissue; brain; genitourinary system; gut; and hemolymphoid system gland. Orthologous to human NCOA7 (nuclear receptor coactivator 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Ncoa7 |
| Official Name | nuclear receptor coactivator 7 [Source:MGI Symbol;Acc:MGI:2444847] |
| Ensembl ID | ENSMUSG00000039697 |
| Bio databases IDs | |
| Aliases | nuclear receptor coactivator 7 |
| Synonyms | 9030406N13RIK, dJ187J11.3, ERAP140, ESNA1, Nbla00052, Nbla10993, NCOA7-AS, nuclear receptor coactivator 7, RGD1566426, TLDC4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ncoa7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- LysM domain
- transcription regulator
- ligand-dependent nuclear receptor interactor
- LXXLL motif
- transcription co-activator
- Lysin Motif is a small domain involved in binding peptidoglycan
- TLD
- protein binding
- Lysin motif
Pathways
Biological processes and signaling networks where the Ncoa7 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- non-insulin-dependent diabetes mellitus
- hypertension
- gout
- prostatic intraepithelial neoplasm
- prostatic intraepithelial neoplasia
- Brugada syndrome
- survival
- self-abusive behavior
regulates
- RNA polymerase II
- RAR
- DNA endogenous promoter
- DNA promoter
- ESR1
- AHR/ARNT/aryl hydrocarbon
role in cell
- cell death
- transformation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ncoa7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to oxidative stress
- negative regulation of cellular response to oxidative stress
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- ligand-dependent nuclear receptor binding
- protein binding
- ligand-dependent nuclear receptor transcription coactivator activity