Fkbp6 Gene Summary [Mouse]
This gene is a member of the FK506-binding protein (Fkbp) family. The encoded protein plays a role in male-specific fertility and homologous pairing of chromosomes during meiosis. The protein may also be involved in LINE1 transposon silencing and binding to Hsp90 as a co-chaperone. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2013]
Details
| Type | Protein Coding |
| Official Symbol | Fkbp6 |
| Official Name | FK506 binding protein 6 [Source:MGI Symbol;Acc:MGI:2137612] |
| Ensembl ID | ENSMUSG00000040013 |
| Bio databases IDs | |
| Aliases | FK506 binding protein 6 |
| Synonyms | 1700008G22Rik, D5Ertd724e, FK506 binding protein 6, FKBP-36, FKBP prolyl isomerase family member 6, FKBP prolyl isomerase family member 6 (inactive), PPIase, SPGF77 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fkbp6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FKBP-type peptidyl-prolyl cis-trans isomerase
- peptidylprolyl isomerase
- FK506 binding
- heat shock protein binding
- enzyme
- protein binding
- identical protein binding
- tetratricopeptide repeat
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- microtubule cytoskeleton
- fibrillar center
- Cytoplasm
- cytoplasmic bridges
- cytosol
- nucleoplasm
- synaptonemal complexes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fkbp6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- meiotic cell cycle
- spermatogenesis
- cell differentiation
- gene silencing by RNA
- piRNA metabolic process
- protein folding
- positive regulation of viral genome replication
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- synaptonemal complex
Molecular Function
What the gene product does at the molecular level
- peptidyl-prolyl cis-trans isomerase activity
- identical protein binding
- protein binding
- FK506 binding
- Hsp90 protein binding