Gramd1b Gene Summary [Mouse]
Enables cholesterol binding activity; cholesterol transfer activity; and phospholipid binding activity. Involved in cellular response to cholesterol and cholesterol homeostasis. Located in endoplasmic reticulum membrane; endoplasmic reticulum-plasma membrane contact site; and plasma membrane. Is expressed in several structures, including adrenal medulla; brain; retina; and testis. Orthologous to human GRAMD1B (GRAM domain containing 1B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gramd1b |
| Official Name | GRAM domain containing 1B [Source:MGI Symbol;Acc:MGI:1925037] |
| Ensembl ID | ENSMUSG00000040111 |
| Bio databases IDs | |
| Aliases | GRAM domain containing 1B |
| Synonyms | 3222402H23, A930008A22Rik, GRAM domain containing 1B, KIAA1201, LINC01059, LOC100128242, LOC103693058, mKIAA1201, RGD1305443 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gramd1b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid transporter
- phospholipid binding
- cholesterol binding
- binding protein
- Pleckstrin homology-like domain
- VAD1 Analog of StAR-related lipid transfer domain
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- ulcerative colitis
- chronic lymphocytic leukemia
- acute myeloid leukemia
- plasma cell myeloma
- follicular non-Hodgkin disease
- refractive error
- non-Hodgkin disease
- lymphocytic leukemia
- survival
role in cell
- proliferation
- expression in
- colony formation
- response by
- molecular cleavage in
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Plasma Membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- organelle membrane contact site
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gramd1b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to cholesterol
- intracellular sterol transport
- cholesterol homeostasis
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylserine binding
- cholesterol binding
- phosphatidic acid binding