Trappc4 Gene Summary [Mouse]
Involved in dendrite development. Located in Golgi stack; dendrite; and synaptic vesicle. Part of TRAPP complex. Is active in postsynaptic density membrane and presynaptic active zone. Is expressed in central nervous system; ganglia; olfactory epithelium; thymus primordium; and tooth. Orthologous to human TRAPPC4 (trafficking protein particle complex subunit 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Trappc4 |
| Official Name | trafficking protein particle complex 4 [Source:MGI Symbol;Acc:MGI:1926211] |
| Ensembl ID | ENSMUSG00000032112 |
| Bio databases IDs | |
| Aliases | trafficking protein particle complex 4 |
| Synonyms | 1500017G03Rik, CGI-104, HSPC172, NEDESBA, PTD009, Sbd, SBDN, Sdcbp2, SYNBINDIN, trafficking protein particle complex 4, trafficking protein particle complex subunit 4, TRS23 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trappc4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PDZ-like domain
- Sedlin, N-terminal conserved region
- protein binding
- Longin-like domains
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- neurodevelopmental disorder with epilepsy, spasticity, and brain atrophy
- neurodevelopmental disorder with progressive microcephaly spasticity and brain anomalies
role in cell
- expression in
- apoptosis
- activation
- degradation in
- development
- cellular infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane fractions
- synaptic plasma membrane fractions
- Plasma Membrane
- intracellular storage compartment
- vesicles
- Golgi Apparatus
- cytosol
- cisternae
- presynaptic membrane
- postsynaptic membrane
- synaptic membrane
- Golgi stacks
- dendritic spines
- synaptic vesicles
- synaptosomes
- synapse
- recycling endosomes
- cellular protrusions
- perikaryon
- dendrites
- dendritic shafts
- apical processes
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trappc4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vesicle coating
- ER to Golgi vesicle-mediated transport
- autophagy
- dendrite development
- COPII vesicle coating
Cellular Component
Where in the cell the gene product is active
- TRAPP complex
- dendrite
- postsynaptic membrane
- cytoplasm
- synaptic vesicle
- cytosol
- endoplasmic reticulum
- Golgi membrane
- synapse
- Golgi stack
Molecular Function
What the gene product does at the molecular level
- protein binding