Alx4 Gene Summary [Mouse]
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; HMG box domain binding activity; and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including embryonic limb morphogenesis; embryonic skeletal system morphogenesis; and roof of mouth development. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including central nervous system; embryo mesenchyme; genitourinary system; integumental system; and sensory organ. Used to study parietal foramina. Human ortholog(s) of this gene implicated in craniosynostosis; frontonasal dysplasia 2; gastrointestinal system cancer (multiple); lung cancer (multiple); and parietal foramina. Orthologous to human ALX4 (ALX homeobox 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Alx4 |
| Official Name | aristaless-like homeobox 4 [Source:MGI Symbol;Acc:MGI:108359] |
| Ensembl ID | ENSMUSG00000040310 |
| Bio databases IDs | |
| Aliases | aristaless-like homeobox 4 |
| Synonyms | ALX homeobox 4, aristaless-like homeobox 4, CRS5, FND2, lst |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Alx4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- OAR motif
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- nucleic acid binding
- protein domain specific binding
- protein binding
- sequence-specific DNA binding
- proline rich domain
- Sh3 domain binding motif
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- homeodomain
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- developmental disorder
- parietal foramina 2
- hereditary disorder
- frontonasal dysplasia type 2
- herniation
- exencephaly
- polydactyly
- eyelids open at birth
- susceptibility to craniosynostosis 5
regulates
- reporter gene
- NCAM1
- DNA promoter
- DNA endogenous promoter
- RNA polymerase II
role in cell
- apoptosis
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Alx4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- palate development
- post-embryonic development
- anterior/posterior pattern specification
- regulation of apoptotic process
- positive regulation of transcription from RNA polymerase II promoter
- embryonic skeletal system morphogenesis
- regulation of transcription from RNA polymerase II promoter
- embryonic digit morphogenesis
- muscle organ development
- skeletal system development
- hair follicle development
- digestive tract development
- embryonic forelimb morphogenesis
- embryonic hindlimb morphogenesis
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- nucleus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- HMG box domain binding
- protein binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity