Aqr Gene Summary [Mouse]
Predicted to enable 3'-5' RNA helicase activity; mRNA binding activity; and single-stranded RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in nucleoplasm. Predicted to be part of U2-type catalytic step 2 spliceosome. Orthologous to human AQR (aquarius intron-binding spliceosomal factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Aqr |
| Official Name | aquarius [Source:MGI Symbol;Acc:MGI:1276102] |
| Ensembl ID | ENSMUSG00000040383 |
| Bio databases IDs | |
| Aliases | aquarius |
| Synonyms | aquarius, aquarius intron-binding spliceosomal factor, fSAP164, IBP160, mKIAA0560 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Aqr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- N-terminal helicase domain of the DEAD-box helicase superfamily
- enzyme
- protein binding
- UvrD-like helicase C-terminal domain
- RNA helicase
- single-stranded RNA binding
- P-loop containing Nucleoside Triphosphate Hydrolases
- Intron-binding protein aquarius N-terminus
- AAA domain
Pathways
Biological processes and signaling networks where the Aqr gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- catalytic step 2 spliceosome
- spliceosomes
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Aqr gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- catalytic step 2 spliceosome
- membrane
- U2-type catalytic step 2 spliceosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- RNA binding
- protein binding
- single-stranded RNA binding
- mRNA binding
- 3'-5' RNA helicase activity