Rpl35a Gene Summary [Mouse]

A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation; rRNA processing; and ribosomal large subunit biogenesis. Located in cytoplasm. Part of cytosolic large ribosomal subunit. Is active in synapse. Is expressed in central nervous system; cranium; gut; inner ear; and submandibular gland primordium. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 5. Orthologous to human RPL35A (ribosomal protein L35a). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Rpl35a
Official Name
ribosomal protein L35A [Source:MGI Symbol;Acc:MGI:1928894]
Ensembl ID
ENSMUSG00000060636
Bio databases IDs NCBI: 57808 Ensembl: ENSMUSG00000060636
Aliases ribosomal protein L35A
Synonyms 2810431L15Rik, DBA5, eL33, L35A, ribosomal protein L35A, Rpl35, Rpl35al1
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rpl35a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • structural constituent of ribosome
  • Ribosomal protein L35Ae
  • ribonucleoprotein binding
  • protein binding

Pathways

Biological processes and signaling networks where the Rpl35a gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • Diamond-Blackfan anemia
  • diamond-blackfan anemia type 5
regulated by
regulates
role in cell
  • cell death
  • cell viability
  • translation in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • ribosome
  • cytosol
  • nucleoli
  • synapse

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Rpl35a gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • cytoplasmic translation
  • ribosomal large subunit biogenesis
  • rRNA processing
  • translation

Cellular Component

Where in the cell the gene product is active
  • extracellular vesicular exosome
  • cytosolic ribosome
  • cytoplasm
  • membrane
  • cytosol
  • cytosolic large ribosomal subunit

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • RNA binding
  • structural constituent of ribosome
  • tRNA binding

Gene-Specific Assays for Results You Can Trust

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