Otud6b Gene Summary [Mouse]
Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in several processes, including proteasome assembly; protein deubiquitination; and regulation of translation. Predicted to be part of eukaryotic translation initiation factor 4F complex. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and liver and biliary system. Orthologous to human OTUD6B (OTU deubiquitinase 6B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Otud6b |
| Official Name | OTU domain containing 6B [Source:MGI Symbol;Acc:MGI:1919451] |
| Ensembl ID | ENSMUSG00000040550 |
| Bio databases IDs | |
| Aliases | OTU domain containing 6B |
| Synonyms | 2600013N14Rik, CGI-77, DUBA-5, IDDFSDA, OTU deubiquitinase 6B, OTU domain containing 6B, RGD1310024 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Otud6b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptidase
- ubiquitin-specific protease
- protein binding
- OTU-like cysteine protease
- OTU (ovarian tumor) domain family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- epithelial cancer
- hepatocellular carcinoma
- liver cancer
- intellectual developmental disorder with dysmorphic facies, seizures and distal limb anomaly
- hereditary disorder
- syndromic mental retardation
- breast carcinoma
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
role in cell
- growth
- proliferation
- formation
- formation in
- migration
- frequency
- ubiquitination in
- breakage in
- tanespimycin resistance
- double-stranded DNA break repair in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Otud6b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein deubiquitination
- cell proliferation
- proteolysis
- proteasome assembly
Cellular Component
Where in the cell the gene product is active
- eukaryotic translation initiation factor 4F complex
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- protein binding