OTUD6B Gene Summary [Human]
This gene encodes a member of the ovarian tumor domain (OTU)-containing subfamily of deubiquitinating enzymes. Deubiquitinating enzymes are primarily involved in removing ubiquitin from proteins targeted for degradation. This protein may function as a negative regulator of the cell cycle in B cells. [provided by RefSeq, Nov 2013]
Details
| Type | Protein Coding |
| Official Symbol | OTUD6B |
| Official Name | OTU deubiquitinase 6B [Source:HGNC Symbol;Acc:HGNC:24281] |
| Ensembl ID | ENSG00000155100 |
| Bio databases IDs | |
| Aliases | OTU deubiquitinase 6B |
| Synonyms | 2600013N14Rik, CGI-77, DUBA-5, IDDFSDA, OTU deubiquitinase 6B, OTU domain containing 6B, RGD1310024 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human OTUD6B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptidase
- ubiquitin-specific protease
- protein binding
- OTU-like cysteine protease
- OTU (ovarian tumor) domain family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- epithelial cancer
- hepatocellular carcinoma
- liver cancer
- intellectual developmental disorder with dysmorphic facies, seizures and distal limb anomaly
- hereditary disorder
- syndromic mental retardation
- breast carcinoma
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
role in cell
- growth
- proliferation
- formation
- formation in
- migration
- frequency
- ubiquitination in
- breakage in
- tanespimycin resistance
- double-stranded DNA break repair in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human OTUD6B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein deubiquitination
- cell proliferation
- proteolysis
- proteasome assembly
Cellular Component
Where in the cell the gene product is active
- eukaryotic translation initiation factor 4F complex
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- protein binding