Kremen2 Gene Summary [Mouse]
Predicted to enable transmembrane signaling receptor activity. Involved in limb development and negative regulation of ossification. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including genitourinary system; integumental system; sensory organ; skeletal musculature; and tooth. Orthologous to human KREMEN2 (kringle containing transmembrane protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kremen2 |
| Official Name | kringle containing transmembrane protein 2 [Source:MGI Symbol;Acc:MGI:1920266] |
| Ensembl ID | ENSMUSG00000040680 |
| Bio databases IDs | |
| Aliases | kringle containing transmembrane protein 2 |
| Synonyms | 2900054E04Rik, kringle containing transmembrane protein 2, KRM2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kremen2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- KR
- WSC domain
- present in yeast cell wall integrity and stress response component proteins
- CUB
- protein binding
Pathways
Biological processes and signaling networks where the Kremen2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- neoplasia
- colon cancer
- colon epithelial cancer
- organismal death
- lung adenocarcinoma
- lung adenocarcinoma formation
- polydactyly
- colon adenocarcinoma
- soft tissue sarcoma cancer
role in cell
- expression in
- quantity
- proliferation
- migration
- number
- surface area
- abnormal morphology
- ossification by
- polyubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- cellular membrane
- Plasma Membrane
- endosomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kremen2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- limb development
- multicellular organismal development
- Wnt receptor signaling pathway
- negative regulation of ossification
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- plasma membrane