Mgrn1 Gene Summary [Mouse]
Enables ubiquitin protein ligase activity. Involved in negative regulation of smoothened signaling pathway. Acts upstream of or within several processes, including heart development; protein polyubiquitination; and smoothened signaling pathway. Part of ubiquitin ligase complex. Is expressed in several structures, including genitourinary system; heart; node; and skin. Orthologous to human MGRN1 (mahogunin ring finger 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mgrn1 |
| Official Name | mahogunin, ring finger 1 [Source:MGI Symbol;Acc:MGI:2447670] |
| Ensembl ID | ENSMUSG00000022517 |
| Bio databases IDs | |
| Aliases | mahogunin, ring finger 1 |
| Synonyms | 2610042J20Rik, Mahganoid, Mahogunin, mahogunin ring finger 1, mahogunin, ring finger 1, md, mKIAA0544, nc, RGD1311862, RNF156 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mgrn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- enzyme
- Ring finger domain
- PSAP motif
- protein binding
- Zinc finger, C3HC4 type (RING finger)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prion disease
- familial adenomatous polyposis
role in cell
- expression in
- ubiquitination in
- morphology
- number
- signaling in
- degradation in
- pH
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Nucleus
- Plasma Membrane
- endosomes
- vesicles
- Endoplasmic Reticulum
- cytosol
- early endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mgrn1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein polyubiquitination
- endosome to lysosome transport
- protein monoubiquitination
- negative regulation of cAMP-mediated signaling
- negative regulation of smoothened signaling pathway
- negative regulation of G-protein coupled receptor protein signaling pathway
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- early endosome
- extracellular vesicular exosome
- cytoplasm
- intracellular membrane-bounded organelle
- membrane
- cytosol
- endoplasmic reticulum
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding
- metal ion binding