Kremen2 Gene Summary [Rat]
Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in limb development; negative regulation of ossification; and signal transduction. Predicted to be active in plasma membrane. Orthologous to human KREMEN2 (kringle containing transmembrane protein 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kremen2 |
| Official Name | kringle containing transmembrane protein 2 [Source:RGD Symbol;Acc:1310795] |
| Ensembl ID | ENSRNOG00000004122 |
| Bio databases IDs | |
| Aliases | kringle containing transmembrane protein 2 |
| Synonyms | 2900054E04Rik, kringle containing transmembrane protein 2, KRM2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Kremen2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- KR
- WSC domain
- present in yeast cell wall integrity and stress response component proteins
- CUB
- protein binding
Pathways
Biological processes and signaling networks where the Kremen2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- neoplasia
- colon cancer
- colon epithelial cancer
- organismal death
- lung adenocarcinoma
- lung adenocarcinoma formation
- polydactyly
- colon adenocarcinoma
- soft tissue sarcoma cancer
role in cell
- expression in
- quantity
- proliferation
- migration
- number
- surface area
- abnormal morphology
- ossification by
- polyubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- cellular membrane
- Plasma Membrane
- endosomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Kremen2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- limb development
- multicellular organismal development
- Wnt receptor signaling pathway
- negative regulation of ossification
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- plasma membrane