Rsc1a1 Gene Summary [Mouse]
The protein encoded by this intronless gene inhibits the expression of the solute carrier family 5 (sodium/glucose cotransporter), member 1 gene (SLC5A1) and downregulates exocytosis of the SLC5A1 protein. The encoded protein is sometimes found coating the trans-Golgi network and other times is localized to the nucleus, depending on the cell cycle stage. This protein also inhibits the expression of solute carrier family 22 (organic cation transporter), member 2 (SLC22A2). [provided by RefSeq, Dec 2015]
Details
| Type | Protein Coding |
| Official Symbol | Rsc1a1 |
| Official Name | regulatory solute carrier protein, family 1, member 1 [Source:MGI Symbol;Acc:MGI:3526447] |
| Ensembl ID | ENSMUSG00000040715 |
| Bio databases IDs | |
| Aliases | regulatory solute carrier protein, family 1, member 1 |
| Synonyms | 1110056G13RIK, 1700027M01RIK, regulator of solute carriers 1, regulatory solute carrier protein, family 1, member 1, RS1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rsc1a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- sodium channel inhibitor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cell junction
- cellular membrane
- nucleoplasm
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rsc1a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of glucose transport
- negative regulation of transport
- negative regulation of nucleoside transport
- negative regulation of Golgi to plasma membrane protein transport
Cellular Component
Where in the cell the gene product is active
- cell junction
- Golgi apparatus
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- sodium channel inhibitor activity