Zfhx2 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in regulation of sensory perception of pain. Acts upstream of or within adult behavior. Located in nucleus. Is expressed in several structures, including gut; male reproductive system; musculature; nervous system; and urinary system. Used to study Marsili syndrome. Human ortholog(s) of this gene implicated in Marsili syndrome. Orthologous to human ZFHX2 (zinc finger homeobox 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zfhx2 |
| Official Name | zinc finger homeobox 2 [Source:MGI Symbol;Acc:MGI:2686934] |
| Ensembl ID | ENSMUSG00000040721 |
| Bio databases IDs | |
| Aliases | zinc finger homeobox 2 |
| Synonyms | LOC100505868, MARSIS, ZFH, ZFH-5, zinc finger homeobox 2, ZNF409 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zfhx2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- C2H2-type zinc-finger domain
- protein binding
- Zinc-finger of C2H2 type
- homeodomain
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zfhx2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of neuron differentiation
- adult behavior
- regulation of sensory perception of pain
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity