Plekhh2 Gene Summary [Mouse]
Enables actin binding activity. Involved in negative regulation of actin filament depolymerization. Located in cortical actin cytoskeleton. Is expressed in s-shaped body. Orthologous to human PLEKHH2 (pleckstrin homology, MyTH4 and FERM domain containing H2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Plekhh2 |
| Official Name | pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 [Source:MGI Symbol;Acc:MGI:2146813] |
| Ensembl ID | ENSMUSG00000040852 |
| Bio databases IDs | |
| Aliases | pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 |
| Synonyms | E030001K05, mKIAA2028, pleckstrin homology domain containing, family H (with MyTH4 domain) member 2, pleckstrin homology, MyTH4 and FERM domain containing H2, PLEKHH1L, RGD1304935 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Plekhh2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FERM central domain
- Band 4.1 homologues
- Autophagy protein 16 (ATG16)
- Ezrin/radixin/moesin, alpha-helical domain
- actin binding
- Ubl1_cv_Nsp3_N-like
- Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
- PH domain
- protein binding
- Pleckstrin homology-like domain
- FERM domain B-lobe
- MyTH4 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- colon cancer
- non-small cell lung cancer
- organismal death
- colorectal cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- cholelithiasis
- coronary artery disease
role in cell
- expression in
- phosphorylation in
- proliferation
- migration
- invasion by
- depolymerization
- interaction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cortical actin cytoskeleton
- Plasma Membrane
- cytosol
- nucleoplasm
- nuclear bodies
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Plekhh2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of actin filament depolymerization
Cellular Component
Where in the cell the gene product is active
- nuclear body
- cytoplasm
- cytosol
- cortical actin cytoskeleton
- plasma membrane
- lamellipodium
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- actin binding