Lpxn Gene Summary [Mouse]
Enables transcription coregulator activity. Involved in negative regulation of B cell receptor signaling pathway and regulation of cell adhesion mediated by integrin. Located in focal adhesion; nucleus; and podosome. Is expressed in central nervous system; genitourinary system; and thymus. Orthologous to human LPXN (leupaxin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lpxn |
| Official Name | leupaxin [Source:MGI Symbol;Acc:MGI:2147677] |
| Ensembl ID | ENSMUSG00000024696 |
| Bio databases IDs | |
| Aliases | leupaxin |
| Synonyms | 4933402K05RIK, A530083L21RIK, LDPL, LEUPAXIN |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lpxn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- LIM is a small protein-protein interaction domain, containing two zinc fingers
- transcription cofactor
- protein binding
- paxillin LD motif
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- peripheral arterial disease
- metastasis
- inflammatory bowel disease
- ulcerative colitis
- laser induced choroidal neovascularization
- open-angle glaucoma
role in cell
- expression in
- ubiquitination in
- adhesion
- size
- cell spreading
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- focal adhesions
- podosomes
- Nucleus
- Plasma Membrane
- cytosol
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lpxn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell adhesion mediated by integrin
- macromolecular complex assembly
- signal transduction
- negative regulation of cell adhesion
- substrate adhesion-dependent cell spreading
- transforming growth factor beta receptor signaling pathway
- negative regulation of B cell receptor signaling pathway
- cell adhesion
- endothelial cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- focal adhesion
- cytoplasm
- nuclear speck
- membrane
- cytosol
- cell projection
- plasma membrane
- podosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription cofactor activity
- metal ion binding