Map7d2 Gene Summary [Mouse]
Enables kinesin binding activity and microtubule binding activity. Involved in microtubule cytoskeleton organization. Located in microtubule cytoskeleton; midbody; and neuron projection. Is expressed in nervous system. Orthologous to human MAP7D2 (MAP7 domain containing 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Map7d2 |
| Official Name | MAP7 domain containing 2 [Source:MGI Symbol;Acc:MGI:1917474] |
| Ensembl ID | ENSMUSG00000041020 |
| Bio databases IDs | |
| Aliases | MAP7 domain containing 2 |
| Synonyms | 1600028E09Rik, 2900002G04Rik, 5330432J06Rik, Brelin, C030036K04Rik, FLJ14503, MAP7 domain containing 2, Mtap7d2, RGD1564852 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Map7d2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding
- MAP7 (E-MAP-115) family
- zDHHC ankyrin repeat binding domain
- kinesin binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung adenocarcinoma
- lung adenocarcinoma formation
- schizophrenia
- X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia
- EGFR mutation positive adenocarcinoma of the lung
- EGFR mutation positive non-small cell lung cancer
- EGFR expression positive non-squamous non-small cell lung cancer
- age-related hearing loss
role in cell
- organization
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- microtubule cytoskeleton
- centrosome
- microtubules
- midbody
- neurites
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Map7d2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- microtubule cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton