Grid2 Gene Summary [Mouse]
Enables PDZ domain binding activity and scaffold protein binding activity. Involved in several processes, including cerebellar granule cell differentiation; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; and regulation of postsynaptic density assembly. Acts upstream of or within several processes, including chemical synaptic transmission; prepulse inhibition; and regulation of neuron apoptotic process. Located in dendritic spine and postsynaptic membrane. Part of ionotropic glutamate receptor complex. Is active in glutamatergic synapse; parallel fiber to Purkinje cell synapse; and postsynaptic density membrane. Is expressed in several structures, including brain; eye; genitourinary system; intestine; and spinal cord. Used to study autosomal recessive spinocerebellar ataxia 18. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 18. Orthologous to human GRID2 (glutamate ionotropic receptor delta type subunit 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Grid2 |
| Official Name | glutamate receptor, ionotropic, delta 2 [Source:MGI Symbol;Acc:MGI:95813] |
| Ensembl ID | ENSMUSG00000071424 |
| Bio databases IDs | |
| Aliases | glutamate receptor, ionotropic, delta 2 |
| Synonyms | B230104L07Rik, cpr, GluD2, GluR Delta1, GluRdelta2, Glur δ 2, glutamate ionotropic receptor delta type subunit 2, glutamate ionotropic receptor δ type subunit 2, Glutamate receptor channel delta 2, Glutamate receptor channel δ 2, glutamate receptor, ionotropic, delta 2, glutamate receptor, ionotropic, δ 2, ho, Lc, MMS10-AC, Ms10ac, nmf408, SCAR18, tpr |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Grid2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Receptor family ligand binding region
- dimerization domain
- channel/pore class transporter
- Ligated ion channel L-glutamate- and glycine-binding site
- leucine zipper domain
- extracellular ligand-gated ion channel
- protein binding
- identical protein binding
- ion channel
- glutamate receptor
- PDZ-domain binding
- neurotransmitter receptor
- Type 1 periplasmic binding fold superfamily
- Type 2 periplasmic binding fold superfamily
- ligand-gated ion channel
- PDZ binding motif
Pathways
Biological processes and signaling networks where the Grid2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- autosomal recessive spinocerebellar ataxia type 18
- hereditary disorder
- schizophrenia
- osteoarthritis
- ataxia
- pervasive developmental disorder
- neurodegeneration
- metabolic syndrome X
- non-melanoma skin cancer
- obsessive-compulsive disorder
phenotypes
- Purkinje cell degeneration
- abnormal CNS synapse formation
- abnormal CNS synaptic transmission
- abnormal GABA-mediated receptor currents
- abnormal Purkinje cell dendrite morphology
- abnormal Purkinje cell innervation
- abnormal Purkinje cell morphology
- abnormal action potential
- abnormal autophagy
- abnormal cerebellar Purkinje cell layer
- abnormal cerebellar cortex morphology
- abnormal cerebellar foliation
- abnormal cerebellar granule layer morphology
- abnormal cerebellar molecular layer
- abnormal cerebellum development
- abnormal cerebellum lobule morphology
- abnormal cerebellum morphology
- abnormal cochlear VIII nucleus morphology
- abnormal discrimination learning
- abnormal excitatory postsynaptic currents
- abnormal eye blink conditioning behavior
- abnormal eye movement
- abnormal fertility/fecundity
- abnormal gait
- abnormal grooming behavior
- abnormal head movements
- abnormal hindbrain morphology
- abnormal locomotor activation
- abnormal locomotor coordination
- abnormal midbrain morphology
- abnormal miniature inhibitory postsynaptic currents
- abnormal mitochondrion morphology
- abnormal motor capabilities/coordination/movement
- abnormal motor coordination/ balance
- abnormal motor learning
- abnormal myelination
- abnormal neurotransmitter level
- abnormal optokinetic reflex
- abnormal posture
- abnormal reflex
- abnormal response to injury
- abnormal resting posture
- abnormal sensory capabilities/reflexes/nociception
- abnormal sexual interaction
- abnormal spatial learning
- abnormal sperm flagellum morphology
- abnormal sperm motility
- abnormal suckling behavior
- abnormal synapse morphology
- abnormal trigeminal motor nucleus morphology
- abnormal vestibuloocular reflex
- absent gastric milk in neonates
- absent long term depression
- ataxia
- athetotic walking movements
- cerebellum atrophy
- decreased Purkinje cell number
- decreased birth weight
- decreased body size
- decreased body weight
- decreased cerebellar granule cell number
- decreased exploration in new environment
- decreased survivor rate
- decreased vertical activity
- head tilt
- hindlimb paralysis
- hyperactivity
- hypoactivity
- hypoxia
- impaired balance
- impaired coordination
- impaired fertilization
- impaired limb coordination
- impaired righting response
- impaired sperm penetration of zona pellucida
- increased circulating adrenocorticotropin level
- increased circulating corticosterone level
- increased or absent threshold for auditory brainstem response
- increased prepulse inhibition
- jerky movement
- lethality at weaning complete penetrance
- lethargy
- limb grasping
- male infertility
- muscle spasm
- neonatal lethality complete penetrance
- neonatal lethality incomplete penetrance
- postnatal lethality
- reduced cerebellar foliation
- reduced female fertility
- reduced linear vestibular evoked potential
- reduced long term depression
- reduced male fertility
- retropulsion
- short stride length
- small cerebellum
- stereotypic behavior
- thin cerebellar molecular layer
- thin external granule cell layer
- titubation
- tremors
- weaving
role in cell
- size
- apoptosis
- cell death
- differentiation
- function
- degeneration
- formation
- formation in
- transformation
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- postsynaptic density (PSD) fractions
- membrane fraction
- synaptosomal membrane fractions
- glutaminergic synapse
- Cytoplasm
- somatodendritic region
- cellular membrane
- postsynaptic membrane
- synaptic membrane
- dendritic spines
- synaptosomes
- synapse
- postsynaptic density
- excitatory synapses
- dendritic shafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Grid2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cerebellar granule cell differentiation
- regulation of excitatory postsynaptic membrane potential
- prepulse inhibition
- ion transmembrane transport
- protein localization
- heterophilic cell-cell adhesion
- positive regulation of long term synaptic depression
- regulation of neuron apoptotic process
- glutamate receptor signaling pathway
- regulation of synaptic transmission
- regulation of neuron projection development
- positive regulation of synapse assembly
- synaptic transmission, glutamatergic
Cellular Component
Where in the cell the gene product is active
- dendritic spine
- synapse
- ionotropic glutamate receptor complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- scaffold protein binding
- identical protein binding
- protein binding
- glutamate receptor activity
- PDZ domain binding