Gucy1a2 Gene Summary [Mouse]
Predicted to enable guanylate cyclase activity. Acts upstream of or within positive regulation of nitric oxide mediated signal transduction. Predicted to be part of guanylate cyclase complex, soluble. Is expressed in several structures, including adrenal gland; nervous system; and urinary system. Orthologous to human GUCY1A2 (guanylate cyclase 1 soluble subunit alpha 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gucy1a2 |
| Official Name | guanylate cyclase 1, soluble, alpha 2 [Source:MGI Symbol;Acc:MGI:2660877] |
| Ensembl ID | ENSMUSG00000041624 |
| Bio databases IDs | |
| Aliases | guanylate cyclase 1, soluble, alpha 2 |
| Synonyms | 6330407I18Rik, A230060L24Rik, Alpha 2 GC, GC-SA2, GCS-alpha-2, GCS-α-2, guanylate cyclase 1, soluble, alpha 2, guanylate cyclase 1 soluble subunit alpha 2, guanylate cyclase 1 soluble subunit α 2, guanylate cyclase 1, soluble, α 2, GUC1A2, LOC497842, Nogc alpha2 subunit, NO-SENSITIVE GUANYLYL CYCLASE, sGCalpha2, α 2 GC |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gucy1a2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Heme NO binding associated
- binding protein
- guanylate cyclase
- Class III nucleotidyl cyclases
- enzyme
- protein binding
- Adenylyl- / guanylyl cyclase, catalytic domain
Pathways
Biological processes and signaling networks where the Gucy1a2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Adrenomedullin signaling pathway
- Antiproliferative Role of Somatostatin Receptor 2
- Cellular Effects of Sildenafil (Viagra)
- Circadian Rhythm Signaling
- Corticotropin Releasing Hormone Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- Endothelin-1 Signaling
- eNOS Signaling
- Gap Junction Signaling
- Inhibition of Angiogenesis by TSP1
- Nitric Oxide Signaling in the Cardiovascular System
- Phototransduction Pathway
- Relaxin Signaling
- Sertoli Cell-Sertoli Cell Junction Signaling
- Sperm Motility
- Synaptic Long Term Depression
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- congestive heart failure
- essential hypertension
- cardiovascular disorder
- COVID-19
- myocardial infarction
- disorder of coronary artery
- coronary artery disease
- idiopathic scoliosis
- hypertensive crisis
regulates
- nitric oxide
- RAP1
role in cell
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- membrane surface
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gucy1a2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cGMP-mediated signaling
- cGMP biosynthetic process
- response to oxygen levels
- nitric oxide mediated signal transduction
- signal transduction
- positive regulation of nitric oxide mediated signal transduction
Cellular Component
Where in the cell the gene product is active
- guanylate cyclase complex, soluble
- cytosol
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- guanylate cyclase activity
- heme binding