Scrib Gene Summary [Mouse]
Predicted to enable protein kinase binding activity and signaling adaptor activity. Involved in several processes, including establishment of T cell polarity; negative regulation of activated T cell proliferation; and synaptic vesicle cycle. Acts upstream of or within several processes, including nervous system development; post-anal tail morphogenesis; and wound healing. Located in several cellular components, including basolateral plasma membrane; immunological synapse; and myelin sheath abaxonal region. Is expressed in several structures, including embryo mesenchyme; epithelium; metanephros; nervous system; and skin. Used to study prostate cancer. Orthologous to human SCRIB (scribble planar cell polarity protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Scrib |
| Official Name | scribbled planar cell polarity [Source:MGI Symbol;Acc:MGI:2145950] |
| Ensembl ID | ENSMUSG00000022568 |
| Bio databases IDs | |
| Aliases | scribbled planar cell polarity |
| Synonyms | AI118201, CRC, CRIB, CRIB1, KIAA0147, mKIAA0147, oSCRIB, RGD1565055, SCRB1, SCRIB1, scribbled planar cell polarity, scribble planar cell polarity, scribble planar cell polarity protein, Vartul |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Scrib often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Leucine-rich repeats, outliers
- Leucine-rich repeats, typical (most populated) subfamily
- Domain present in PSD-95, Dlg, and ZO-1/2
- ERK-binding site
- protein phosphatase 1 regulatory subunit 42
- protein binding activity, bridging
- canonical PDZ domain
- Leucine rich repeat
- PP1 binding domain
- protein binding
- PDZ domain
- Leucine Rich repeats (2 copies)
- cpPDZ_Deg_HtrA-like
- cpPDZ_RseP_YlbL-like
Pathways
Biological processes and signaling networks where the Scrib gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- inflammatory bowel disease
- neural tube defect
- epithelial neoplasia
- benign neoplasia
- adenoma formation
- epithelial cancer
- cancer
- hyperplasia
- breast carcinoma
- pervasive developmental disorder
role in cell
- expression in
- proliferation
- invasion
- migration
- formation
- activation in
- phosphorylation in
- apoptosis
- binding in
- targeting
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- basal ectoplasmic specialization of blood-testis barrier
- detergent resistant lipid raft fraction
- glutaminergic synapse
- cell junction
- presynaptic regions
- postsynaptic region
- cellular membrane
- Plasma Membrane
- intercellular junctions
- immunological synapses
- granules
- cytosol
- basolateral cell surfaces
- apical membrane
- presynaptic membrane
- postsynaptic membrane
- basolateral membrane
- lateral plasma membrane
- nucleoplasm
- myelin sheath outer loop
- synapse
- anchoring junction
- cell membrane leading edge
- postsynaptic density
- cell-cell adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Scrib gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- embryo development
- apoptotic process involved in morphogenesis
- auditory receptor cell stereocilium organization
- cell proliferation
- establishment of apical/basal cell polarity
- negative regulation of translational initiation
- positive chemotaxis
- mammary gland duct morphogenesis
- wound healing
- neural tube closure
- synaptic vesicle endocytosis
- positive regulation of receptor recycling
- establishment of T cell polarity
- establishment or maintenance of epithelial cell apical/basal polarity
- positive regulation of interferon-gamma production
- protein localization to adherens junction
- cell migration
- astrocyte cell migration
- cochlear nucleus development
- negative regulation of activated T cell proliferation
- negative regulation of mitotic cell cycle
- receptor clustering
- synaptic vesicle targeting
- polarized epithelial cell differentiation
- positive regulation of apoptotic process
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- postsynaptic density
- Scrib-APC-beta-catenin complex
- cell leading edge
- plasma membrane
- nucleoplasm
- immunological synapse
- cell-cell contact zone
- adherens junction
- extracellular vesicular exosome
- cell-cell junction
- postsynaptic membrane
- cell junction
- myelin sheath abaxonal region
- basolateral plasma membrane
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- signaling adaptor activity
- cadherin binding