Amot Gene Summary [Mouse]
Predicted to enable angiostatin binding activity and signaling receptor activity. Acts upstream of or within several processes, including gastrulation; negative regulation of GTPase activity; and vasculogenesis. Located in bicellular tight junction; cytoplasmic vesicle; and lamellipodium. Is expressed in several structures, including egg cylinder; embryo endoderm; embryo mesoderm; and mesendoderm. Orthologous to human AMOT (angiomotin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Amot |
| Official Name | angiomotin [Source:MGI Symbol;Acc:MGI:108440] |
| Ensembl ID | ENSMUSG00000041688 |
| Bio databases IDs | |
| Aliases | angiomotin |
| Synonyms | Angiomotin, CAG-2, D0Kist1, RGD1564027, SII6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Amot often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- signaling receptor activity
- Tropomyosin like
- PPXY motif
- protein binding
- Bin/Amphiphysin/Rvs domain
- identical protein binding
- proline tyrosine motif
- angiostatin binding domain
- SF-assemblin/beta giardin
- Amot coiled-coil homology domain
- Angiomotin C terminal
- Intermediate filament protein
- PDZ binding motif
Pathways
Biological processes and signaling networks where the Amot gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- bleeding
- obesity
- growth failure
- metastasis
- mixed papillary and follicular thyroid cancer
- papillary thyroid carcinoma
- papillary thyroid cancer
- lung cancer
- malignant thyroid gland neoplasm
role in cell
- expression in
- phosphorylation in
- proliferation
- migration
- activation in
- growth
- sphere formation
- invasion by
- binding in
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- F-actin structure
- cell junction
- ruffle
- Cytoplasm
- cell surface
- cellular membrane
- actin filaments
- intercellular junctions
- cell-cell contacts
- cytosol
- membrane ruffles
- plasma membrane extracellular face
- apical membrane
- nucleoplasm
- cytoplasmic vesicles
- endocytotic vesicle
- actin stress fibers
- anchoring junction
- tight junctions
- cell membrane leading edge
- postsynaptic density
- cell-cell adherens junctions
- lamellipodia
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Amot gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of angiogenesis
- protein localization
- establishment of epithelial cell polarity
- vasculogenesis
- blood vessel endothelial cell migration
- establishment of cell polarity involved in ameboidal cell migration
- positive regulation of embryonic development
- chemotaxis
- angiogenesis
- regulation of small GTPase mediated signal transduction
- in utero embryonic development
- cell migration involved in gastrulation
- gastrulation with mouth forming second
- hippo signaling cascade
- regulation of cell migration
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- actin filament
- plasma membrane
- nucleoplasm
- endocytic vesicle
- tight junction
- ruffle
- cytoplasmic vesicle
- cell junction
- cytosol
- signalosome
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- protein binding
- signaling receptor activity
- angiostatin binding