Cdh11 Gene Summary [Mouse]
This gene encodes a type II classical cadherin and preproprotein that is proteolytically processed to generate a mature protein product. This protein product is an integral membrane protein that mediates calcium-dependent cell-cell adhesion, specifically in the context of bone development. Homozygous knockout mice for this gene exhibit impaired synovium development and reduced bone density. Multiple pseudogenes of this gene have been identified in the genome. [provided by RefSeq, Aug 2015]
Details
| Type | Protein Coding |
| Official Symbol | Cdh11 |
| Official Name | cadherin 11 [Source:MGI Symbol;Acc:MGI:99217] |
| Ensembl ID | ENSMUSG00000031673 |
| Bio databases IDs | |
| Aliases | cadherin 11 |
| Synonyms | CAD11, cadherin 11, Cadherin-11 precursor, CDH11 isoform 1, CDHOB, ESWS, OB, OB-cadherin, OB CADHERIN 1, OSF-4, TBHS2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cdh11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-catenin binding domain
- Cadherin, Y-type LIR-motif
- cytoplasmic domain
- Cadherin repeat-like domain
- cytosolic tail domain
- membrane-proximal domain
Pathways
Biological processes and signaling networks where the Cdh11 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- lymphomagenesis
- arthritis
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- lymphoma
- K/BxN serum transfer arthritis
- rheumatoid arthritis associated interstitial pneumonitis
- venous thromboembolism
- cleft lip
role in cell
- expression in
- number
- apoptosis
- proliferation
- phosphorylation in
- differentiation
- quantity
- formation
- invasion by
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- Cytoplasm
- cell surface
- Extracellular Space
- intracellular space
- cellular membrane
- intercellular junctions
- cell-cell contacts
- synapse
- anchoring junction
- axons
- cell-cell adherens junctions
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cdh11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- calcium-dependent cell-cell adhesion
- cell-cell junction assembly
- adherens junction organization
- multicellular organismal development
- cell morphogenesis
- corticospinal tract morphogenesis
- cell adhesion
- homophilic cell adhesion
- aortic valve formation
- skeletal system development
- ossification
- cell-cell adhesion mediated by cadherin
- regulation of synaptic transmission
- focal adhesion assembly
- cell migration
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- adherens junction
- extracellular vesicular exosome
- cytoplasm
- catenin complex
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- calcium ion binding
- cadherin binding
- beta-catenin binding