Cox6a1 Gene Summary [Mouse]

Predicted to enable enzyme regulator activity. Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen. Located in mitochondrion and myelin sheath. Is expressed in several structures, including alimentary system; cranium; genitourinary system; nervous system; and sensory organ. Used to study Charcot-Marie-Tooth disease recessive intermediate D. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease recessive intermediate D. Orthologous to human COX6A1 (cytochrome c oxidase subunit 6A1). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Cox6a1
Official Name
cytochrome c oxidase subunit 6A1 [Source:MGI Symbol;Acc:MGI:103099]
Ensembl ID
ENSMUSG00000041697
Bio databases IDs NCBI: 12861 Ensembl: ENSMUSG00000041697
Aliases cytochrome c oxidase subunit 6A1
Synonyms CMTRID, COX6A, COX6AL, cytochrome c oxidase subunit 6A1, VIaL
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cox6a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • cytochrome-c oxidase
  • Cyt_c_Oxidase_VIa
  • enzyme
  • protein binding

Pathways

Biological processes and signaling networks where the Cox6a1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • peripheral neuropathy
  • lichen planus
  • Charcot-Marie-Tooth disease recessive intermediate type D
regulated by
regulates
  • cytochrome-c oxidase
role in cell
  • replication in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • Mitochondria
  • mitochondrial membrane
  • mitochondrial inner membrane

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Cox6a1 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • generation of precursor metabolites and energy
  • mitochondrial electron transport, cytochrome c to oxygen
  • cellular respiration

Cellular Component

Where in the cell the gene product is active
  • mitochondrial membrane
  • mitochondrion
  • mitochondrial respiratory chain complex IV
  • mitochondrial inner membrane

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • oxidoreductase activity
  • enzyme regulator activity

Gene-Specific Assays for Results You Can Trust

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