Zic5 Gene Summary [Mouse]
Enables DNA-binding transcription factor activity and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within forebrain development; neural crest cell differentiation; and neural tube closure. Located in nucleus. Is expressed in several structures, including central nervous system; early conceptus; limb mesenchyme; sensory organ; and trunk paraxial mesenchyme. Orthologous to human ZIC5 (Zic family member 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zic5 |
| Official Name | zinc finger protein of the cerebellum 5 [Source:MGI Symbol;Acc:MGI:1929518] |
| Ensembl ID | ENSMUSG00000041703 |
| Bio databases IDs | |
| Aliases | zinc finger protein of the cerebellum 5 |
| Synonyms | 1700049L20Rik, Opr, Zic family member 5, zinc finger protein of the cerebellum 5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zic5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- transcription regulator
- nucleic acid binding
- double-stranded DNA binding
- Zinc-finger double domain
- Zic proteins zinc finger domain
- sequence-specific DNA binding
- transcription factor activity
- C2H2-type zinc ribbon
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- metastasis
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
- cholangiocarcinoma
- cholangiocarcinoma cancer
- hydrocephalus
- head and neck squamous cell carcinoma
role in cell
- expression in
- phosphorylation in
- proliferation
- accumulation
- binding in
- apoptosis
- transactivation in
- differentiation
- Wnt signaling in
- enzalutamide resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zic5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- central nervous system development
- cell differentiation
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity