ZIC5 Gene Summary [Human]
This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. The encoded protein may act as a transcriptional repressor. Studies in mouse and Xenopus support a role for this gene in neural crest development. Elevated expression of this gene has been observed in various human cancers and may contribute to cancer progression. This gene is closely linked to a related family member on chromosome 13. [provided by RefSeq, Mar 2017]
Details
| Type | Protein Coding |
| Official Symbol | ZIC5 |
| Official Name | Zic family member 5 [Source:HGNC Symbol;Acc:HGNC:20322] |
| Ensembl ID | ENSG00000139800 |
| Bio databases IDs | |
| Aliases | Zic family member 5 |
| Synonyms | 1700049L20Rik, Opr, Zic family member 5, zinc finger protein of the cerebellum 5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZIC5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- transcription regulator
- nucleic acid binding
- double-stranded DNA binding
- Zinc-finger double domain
- Zic proteins zinc finger domain
- sequence-specific DNA binding
- transcription factor activity
- C2H2-type zinc ribbon
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- metastasis
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
- cholangiocarcinoma
- cholangiocarcinoma cancer
- hydrocephalus
- head and neck squamous cell carcinoma
role in cell
- expression in
- phosphorylation in
- proliferation
- accumulation
- binding in
- apoptosis
- transactivation in
- differentiation
- Wnt signaling in
- enzalutamide resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZIC5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- central nervous system development
- cell differentiation
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity