Myrip Gene Summary [Mouse]
Enables cytoskeletal protein binding activity; protein kinase A binding activity; and small GTPase binding activity. Predicted to be involved in positive regulation of insulin secretion. Predicted to act upstream of or within vesicle transport along actin filament. Located in several cellular components, including actin cytoskeleton; melanosome; and photoreceptor outer segment. Part of exocyst. Is expressed in several structures, including gut; heart; lung; male reproductive gland or organ; and nervous system. Orthologous to human MYRIP (myosin VIIA and Rab interacting protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Myrip |
| Official Name | myosin VIIA and Rab interacting protein [Source:MGI Symbol;Acc:MGI:2384407] |
| Ensembl ID | ENSMUSG00000041794 |
| Bio databases IDs | |
| Aliases | myosin VIIA and Rab interacting protein |
| Synonyms | A230081N12Rik, EXOPHILIN 8, myosin VIIA and Rab interacting protein, SLAC2-C |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Myrip often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase A binding
- enzyme binding
- central domain
- protein binding
- Slp homology domain
- FYVE domain like superfamily
- myosin binding
- actin-binding domain
- myosin-binding domain
- Protein present in Fab1, YOTB, Vac1, and EEA1
- actin binding
- PHD finger superfamily
- Rab effector MyRIP/melanophilin C-terminus
- Rab27 binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- herpes zoster
- pulmonary edema
- mixed connective tissue disease
role in cell
- phosphorylation in
- fusion
- fusion in
- aggregation
- mobility
- transport
- actin-based transport in
- actin-based transport
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- actin cytoskeleton
- cytosol
- apical membrane
- synaptic components
- synapse
- photoreceptor outer segments
- melanosomes
- secretory granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Myrip gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of insulin secretion
- intracellular protein transport
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- melanosome
- dense core granule
- synapse
- transport vesicle
- cortical actin cytoskeleton
- exocyst
- photoreceptor outer segment
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- actin binding
- myosin binding
- small GTPase binding
- protein kinase A binding