Hrnr Gene Summary [Mouse]
Predicted to enable calcium ion binding activity and transition metal ion binding activity. Acts upstream of or within hematopoietic progenitor cell differentiation. Is active in cornified envelope. Is expressed in foregut; limb digit; and skin. Orthologous to human HRNR (hornerin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hrnr |
| Official Name | hornerin [Source:MGI Symbol;Acc:MGI:3046938] |
| Ensembl ID | ENSMUSG00000041991 |
| Bio databases IDs | |
| Aliases | hornerin |
| Synonyms | 1110033K19Rik, A530063N20Rik, AV011854, FLG3, HORNERIN, RGD1307660, S100A16, S100a18 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hrnr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- S-100/ICaBP type calcium binding domain
- EF-hand domain pair
- EFh
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- COVID-19
- liver cancer
- hepatocellular carcinoma
- epithelial cancer
- atopic dermatitis
- colorectal carcinoma
- colorectal carcinomagenesis
role in cell
- differentiation
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cornified envelope
- azurophil granule lumen
- Extracellular Space
- perinuclear region
- keratohyalin granule
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hrnr gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell envelope organization
- keratinization
- establishment of skin barrier
Cellular Component
Where in the cell the gene product is active
- nucleus
- cornified envelope
- extracellular vesicular exosome
- perinuclear region of cytoplasm
- cytoplasm
- extracellular region
- azurophil granule lumen
Molecular Function
What the gene product does at the molecular level
- transition metal ion binding
- calcium ion binding