Dstyk Gene Summary [Mouse]
Predicted to enable ATP binding activity and protein kinase activity. Predicted to be involved in several processes, including cellular response to fibroblast growth factor stimulus; positive regulation of kinase activity; and positive regulation of signal transduction. Located in apical plasma membrane; basolateral plasma membrane; and cytoplasm. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and skin. Human ortholog(s) of this gene implicated in CAKUT1 and hereditary spastic paraplegia 23. Orthologous to human DSTYK (dual serine/threonine and tyrosine protein kinase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dstyk |
| Official Name | dual serine/threonine and tyrosine protein kinase [Source:MGI Symbol;Acc:MGI:1925064] |
| Ensembl ID | ENSMUSG00000042046 |
| Bio databases IDs | |
| Aliases | dual serine/threonine and tyrosine protein kinase |
| Synonyms | A930019K20RIK, C430014H23Rik, C820013G01, CAKUT1, dual serine/threonine and tyrosine protein kinase, DustyPK, Galnt10, HDCMD38P, RHDNS1, RIP5, RIPK5, SPG23 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dstyk often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein kinase (unclassified specificity)
- protein threonine/tyrosine kinase
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- protein binding
- Protein kinase domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Dstyk gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- lung cancer
- non-insulin-dependent diabetes mellitus
- cutaneous melanoma
- cutaneous melanoma cancer
- nonsyndromic renal hypodysplasia 1
- spastic paraplegia type 23
- Dupuytren contracture
- complicated hereditary spastic paraplegia
- coronary artery disease
role in cell
- phosphorylation in
- expression in
- apoptosis
- accumulation in
- growth
- colony formation by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- apical membrane
- basolateral membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dstyk gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of apoptotic process
- positive regulation of ERK1 and ERK2 cascade
- cellular response to fibroblast growth factor stimulus
- positive regulation of fibroblast growth factor receptor signaling pathway
- positive regulation of kinase activity
Cellular Component
Where in the cell the gene product is active
- anchoring junction
- cytoplasm
- basolateral plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein tyrosine kinase activity
- protein binding
- protein serine/threonine/tyrosine kinase activity
- protein serine/threonine kinase activity