Myo3b Gene Summary [Mouse]
Enables microfilament motor activity and protein serine/threonine kinase activity. Involved in inner ear morphogenesis; regulation of actin filament length; and sensory perception of sound. Acts upstream of or within positive regulation of filopodium assembly and protein phosphorylation. Located in filopodium tip; photoreceptor inner segment; and photoreceptor outer segment. Is active in stereocilium tip. Is expressed in several structures, including genitourinary system; nervous system; and submandibular gland. Orthologous to human MYO3B (myosin IIIB). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Myo3b |
| Official Name | myosin IIIB [Source:MGI Symbol;Acc:MGI:2448580] |
| Ensembl ID | ENSMUSG00000042064 |
| Bio databases IDs | |
| Aliases | myosin IIIB |
| Synonyms | A430065P19RIK, LOC102550779, LOC621633, myosin IIIB, RGD1560313 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Myo3b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- IQ (isoleucine-glutamine) motif containing G and D (IQCG and IQCD)
- Protein kinase (unclassified specificity)
- Myosin and Kinesin motor domain
- Protein tyrosine and serine/threonine kinase
- microfilament motor protein
- protein binding
- Protein kinase domain
- Myosin head (motor domain)
- IQ calmodulin-binding motif
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Calmodulin-binding motif
- Protein Kinases, catalytic domain
- Myosin
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- migraines
- acute myeloid leukemia
- coronary aneurysm
- bruxism
- male pattern hair loss
- oral squamous cell carcinoma
- squamous cell cancer of the oral cavity
- osteoporosis
role in cell
- assembly
- length
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- stereocilia tip
- cytosol
- stereocilia
- photoreceptor outer segments
- photoreceptor inner segments
- filopodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Myo3b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sensory perception of sound
- regulation of actin filament length
- cochlea morphogenesis
- positive regulation of filopodium assembly
- visual perception
- peptidyl-serine phosphorylation
Cellular Component
Where in the cell the gene product is active
- myosin complex
- cytoplasm
- filopodium tip
- photoreceptor inner segment
- stereocilium bundle tip
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- actin binding
- protein serine/threonine kinase activity
- microfilament motor activity