Dpysl2 Gene Summary [Mouse]
Enables protein kinase binding activity. Involved in cytoskeleton organization. Acts upstream of or within regulation of neuron projection development. Located in axon; dendrite; and neuronal cell body. Is active in Schaffer collateral - CA1 synapse and postsynaptic density. Is expressed in several structures, including alimentary system; cranium; nervous system; respiratory system; and sensory organ. Orthologous to human DPYSL2 (dihydropyrimidinase like 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dpysl2 |
| Official Name | dihydropyrimidinase-like 2 [Source:MGI Symbol;Acc:MGI:1349763] |
| Ensembl ID | ENSMUSG00000022048 |
| Bio databases IDs | |
| Aliases | dihydropyrimidinase-like 2 |
| Synonyms | CRMP-2, DHPRP2, dihydropyrimidinase-like 2, DRP-2, Musunc33, N2A3, TOAD-64, Tuc-2a, ULIP-2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dpysl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- allantoinase
- protein kinase binding
- dihydropyrimidinase
- dihydroorotase, multifunctional complex type
- Amidohydrolase family
- enzyme
- protein binding
- metallo-dependent_hydrolases
- identical protein binding
- phosphorylation site
- D-hydantoinase
Pathways
Biological processes and signaling networks where the Dpysl2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Alzheimer disease
- esophageal adenocarcinoma
- esophageal carcinoma formation
- breast cancer
- hereditary disorder
- cardiovascular disorder
- schizophrenia
- HER2-positive breast cancer
- pilocarpine-induced status epilepticus
role in cell
- growth
- migration
- invasion by
- expression in
- formation in
- size
- synaptic transmission
- phosphorylation in
- differentiation
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- soluble fraction
- detergent-insoluble fractions
- membrane fraction
- glutaminergic synapse
- microtubule cytoskeleton
- mitotic structure
- presynaptic regions
- cilia
- cell periphery
- perinuclear region
- cellular membrane
- Nucleus
- Plasma Membrane
- microtubules
- midbody
- microtubule tips
- cytosol
- growth cone
- neurites
- myelin sheath
- synapse
- neurite branches
- polar microtubule
- plus end of microtubule
- membrane processes
- central spindle
- mitotic spindle
- perikaryon
- axons
- dendrites
- postsynaptic density
- axon terminals
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dpysl2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- pyrimidine base catabolic process
- cytoskeleton organization
- signal transduction
- nervous system development
- cell differentiation
- endocytosis
- nucleobase-containing compound metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- membrane
- cytosol
- plasma membrane
- microtubule
Molecular Function
What the gene product does at the molecular level
- hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
- identical protein binding
- protein binding
- dihydropyrimidinase activity