Rps18 Gene Summary [Mouse]
A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Part of cytosolic small ribosomal subunit. Is active in synapse. Is expressed in several structures, including brain; genitourinary system; heart; hemolymphoid system gland; and liver. Orthologous to human RPS18 (ribosomal protein S18). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Rps18 |
| Official Name | ribosomal protein S18 [Source:MGI Symbol;Acc:MGI:98146] |
| Ensembl ID | ENSMUSG00000008668 |
| Bio databases IDs | |
| Aliases | ribosomal protein S18 |
| Synonyms | D6S218E, H-2Ke3, HKE3, KE-3, Ribosomal protein s18, S18, uS13 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rps18 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of ribosome
- protein kinase binding
- Ribosomal protein S13/S18
- protein binding
Pathways
Biological processes and signaling networks where the Rps18 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- recurrent implantation failure
- chronic sinusitis
- prostate cancer
- HER2 negative hormone receptor negative breast cancer
- irritable bowel syndrome
- multiple sclerosis
role in cell
- cell death
- fragmentation in
- fragmentation
- processing in
- translation in
- nuclear export in
- tubulation in
- tubulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ribosome
- Nucleus
- cytosol
- nucleoplasm
- nucleoli
- synapse
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rps18 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoplasmic translation
- translation
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- cytosolic ribosome
- cytosolic small ribosomal subunit
- ribosome
- nucleoplasm
- nucleus
- extracellular vesicular exosome
- focal adhesion
- cytoplasm
- membrane
- cytosol
- small ribosomal subunit
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- structural constituent of ribosome
- rRNA binding