Sgsm1 Gene Summary [Mouse]
Enables small GTPase binding activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in cytoplasmic vesicle membrane. Is expressed in several structures, including brain and metanephros. Orthologous to human SGSM1 (small G protein signaling modulator 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sgsm1 |
| Official Name | small G protein signaling modulator 1 [Source:MGI Symbol;Acc:MGI:107320] |
| Ensembl ID | ENSMUSG00000042216 |
| Bio databases IDs | |
| Aliases | small G protein signaling modulator 1 |
| Synonyms | 2410098H20Rik, D5Bwg1524e, E130107M15, NUIP, RUTBC2, small G protein signaling modulator 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sgsm1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rab-GTPase-TBC domain
- domain involved in Ras-like GTPase signaling
- Rab-binding domain (RBD)
- enzyme binding
- GTPase activator
- protein binding
- Pleckstrin homology-like domain
- RUN domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- non-insulin-dependent diabetes mellitus
- astigmatism
- headache
- primary sclerosing cholangitis
role in cell
- expression in
- cell division
- migration
- invasion by
- assembly in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytoplasmic vesicle membrane
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sgsm1 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- cytoplasmic vesicle membrane
- cytoplasm
- cytosol
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- GTPase activator activity
- small GTPase binding