SGSM1 Gene Summary [Human]
Enables GTPase activator activity and small GTPase binding activity. Predicted to be involved in activation of GTPase activity and intracellular protein transport. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Located in cytoplasmic vesicle membrane and cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SGSM1 |
| Official Name | small G protein signaling modulator 1 [Source:HGNC Symbol;Acc:HGNC:29410] |
| Ensembl ID | ENSG00000167037 |
| Bio databases IDs | |
| Aliases | small G protein signaling modulator 1 |
| Synonyms | 2410098H20Rik, D5Bwg1524e, E130107M15, NUIP, RUTBC2, small G protein signaling modulator 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SGSM1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rab-GTPase-TBC domain
- domain involved in Ras-like GTPase signaling
- Rab-binding domain (RBD)
- enzyme binding
- GTPase activator
- protein binding
- Pleckstrin homology-like domain
- RUN domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- non-insulin-dependent diabetes mellitus
- astigmatism
- headache
- primary sclerosing cholangitis
role in cell
- expression in
- cell division
- migration
- invasion by
- assembly in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytoplasmic vesicle membrane
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SGSM1 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- cytoplasmic vesicle membrane
- cytoplasm
- cytosol
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- GTPase activator activity
- small GTPase binding