Shisa3 Gene Summary [Mouse]
Acts upstream of or within negative regulation of canonical Wnt signaling pathway. Predicted to be located in endoplasmic reticulum membrane. Is expressed in several structures, including brain; cranium; embryo mesenchyme; future brain; and gut. Orthologous to human SHISA3 (shisa family member 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Shisa3 |
| Official Name | shisa family member 3 [Source:MGI Symbol;Acc:MGI:3041225] |
| Ensembl ID | ENSMUSG00000050010 |
| Bio databases IDs | |
| Aliases | shisa family member 3 |
| Synonyms | D830007B15Rik, hShisa3, LOC100504147, RGD1565710, shisa family member 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Shisa3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Wnt and FGF inhibitory regulator
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- gastric adenocarcinoma
- gastric epithelial cancer
- lung squamous cell carcinoma
- squamous cell lung cancer
- colon epithelial cancer
- colon adenocarcinoma
regulates
- ERK
- guanosine triphosphate
- RAS
- MEK
- SGSM1
role in cell
- phosphorylation in
- migration
- invasion by
- ubiquitination in
- degradation in
- polyubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Shisa3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of canonical Wnt receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
Molecular Function
What the gene product does at the molecular level
- protein binding