Tbc1d8b Gene Summary [Mouse]
Predicted to enable GTPase activator activity. Predicted to be involved in glomerular filtration and vesicle-mediated transport. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in nephrotic syndrome type 20. Orthologous to human TBC1D8B (TBC1 domain family member 8B). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tbc1d8b |
| Official Name | TBC1 domain family, member 8B [Source:MGI Symbol;Acc:MGI:1918101] |
| Ensembl ID | ENSMUSG00000042473 |
| Bio databases IDs | |
| Aliases | TBC1 domain family, member 8B |
| Synonyms | 4921505D17RIK, 9030605E16Rik, GRAMD8B, NPHS20, RGD1563084, TBC1 domain family member 8B, TBC1 domain family, member 8B |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tbc1d8b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rab-GTPase-TBC domain
- Domain in Tre-2, BUB2p, and Cdc16p
- protein binding
- Pleckstrin homology-like domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tbc1d8b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vesicle-mediated transport
- glomerular filtration
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- GTPase activator activity