Prdm10 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription factor activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be part of transcription repressor complex. Predicted to be active in chromatin and nucleus. Is expressed in several structures, including adrenal medulla; alimentary system; central nervous system; genitourinary system; and heart. Human ortholog(s) of this gene implicated in Birt-Hogg-Dube syndrome. Orthologous to human PRDM10 (PR/SET domain 10). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prdm10 |
| Official Name | PR domain containing 10 [Source:MGI Symbol;Acc:MGI:2682952] |
| Ensembl ID | ENSMUSG00000042496 |
| Bio databases IDs | |
| Aliases | PR domain containing 10 |
| Synonyms | BHD2, Gm1112, PFM7, PR domain containing 10, PR/SET domain 10, RGD1560384, TRIS, tristanin |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Prdm10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- zinc finger
- transcription regulator
- Zinc-finger double-stranded RNA-binding
- Zinc-finger double domain
- SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
- SET domain
- protein binding
- Unstructured region on methyltransferase between zinc-fingers
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Prdm10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription, DNA-dependent
- positive regulation of transcription from RNA polymerase II promoter
- methylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcriptional repressor complex
- chromatin
Molecular Function
What the gene product does at the molecular level
- DNA binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- metal ion binding
- methyltransferase activity