Bhlha15 Gene Summary [Mouse]
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in cellular response to glucose starvation; endoplasmic reticulum unfolded protein response; and negative regulation of myotube differentiation. Acts upstream of or within several processes, including cell-cell adhesion mediated by cadherin; epithelial cell maturation; and intracellular distribution of mitochondria. Located in nucleus. Is expressed in several structures, including alimentary system; early conceptus; exocrine system; genitourinary system; and limb mesenchyme. Orthologous to human BHLHA15 (basic helix-loop-helix family member a15). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bhlha15 |
| Official Name | basic helix-loop-helix family, member a15 [Source:MGI Symbol;Acc:MGI:891976] |
| Ensembl ID | ENSMUSG00000052271 |
| Bio databases IDs | |
| Aliases | basic helix-loop-helix family, member a15 |
| Synonyms | 1810009C13RIK, basic helix-loop-helix family member a15, basic helix-loop-helix family, member a15, bHlH, BHLHB8, MIST-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bhlha15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- nucleic acid binding
- basic Helix Loop Helix (bHLH) domain superfamily
- protein binding
- sequence-specific DNA binding
- identical protein binding
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- helix loop helix domain
- helix-loop-helix domain
- basic domain
- Helix-loop-helix DNA-binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- diabetes mellitus
- pancreatic intraepithelial neoplasia
- pancreatic neoplasia
- intraepithelial neoplasia
- acinar to ductal metaplasia
phenotypes
- abnormal autophagy
- abnormal exocrine pancreas morphology
- abnormal gastric chief cell morphology
- abnormal mammary gland alveolus morphology
- abnormal mammary gland epithelium physiology
- abnormal mammary gland growth during lactation
- abnormal mammary gland luminal epithelium morphology
- abnormal pancreas morphology
- abnormal pancreatic acinar cell morphology
- abnormal pancreatic acinar cell physiology
- abnormal pancreatic acinar cell zymogen granule morphology
- abnormal parotid gland acinus morphology
- abnormal seminal vesicle development
- abnormal seminal vesicle epithelium morphology
- abnormal seminal vesicle fluid composition
- abnormal stomach glandular epithelium morphology
- cachexia
- decreased pancreatic amylase secretion
- enlarged liver
- exocrine pancreatic insufficiency
- hemorrhagic ascites
- increased hepatocellular carcinoma incidence
- increased liver adenoma incidence
- increased mammary gland apoptosis
- increased pancreas adenoma incidence
- increased pancreatic acinar cell carcinoma incidence
- increased tumor incidence
- pancreas fibrosis
- pancreatic acinar hyperplasia
- premature death
- seminal vesicle epithelium degeneration
role in cell
- expression in
- transcription in
- transport in
- differentiation
- formation
- disorganization
- organization
- response by
- formation in
- depletion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bhlha15 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- Golgi organization
- cell-cell signaling
- positive regulation of transcription from RNA polymerase II promoter
- sensory organ development
- cellular response to glucose starvation
- mitochondrial calcium ion transport
- cell-cell junction organization
- type B pancreatic cell maturation
- localization of cell
- endoplasmic reticulum unfolded protein response
- intracellular distribution of mitochondria
- neuron fate commitment
- cell-cell adhesion mediated by cadherin
- glucose homeostasis
- establishment of localization in cell
- negative regulation of myotube differentiation
- calcium-mediated signaling
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- protein dimerization activity
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- E-box binding