PRDM10 Gene Summary [Human]

The protein encoded by this gene is a transcription factor that contains C2H2-type zinc-fingers. It also contains a positive regulatory domain, which has been found in several other zinc-finger transcription factors including those involved in B cell differentiation and tumor suppression. Studies of the mouse counterpart suggest that this protein may be involved in the development of the central nerve system (CNS), as well as in the pathogenesis of neuronal storage disease. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Details

Type
Protein Coding
Official Symbol
PRDM10
Official Name
PR/SET domain 10 [Source:HGNC Symbol;Acc:HGNC:13995]
Ensembl ID
ENSG00000170325
Bio databases IDs NCBI: 56980 Ensembl: ENSG00000170325
Aliases PR/SET domain 10, PRDM zinc finger transcription factor, PR-domain family member 7, tristanin
Synonyms BHD2, Gm1112, PFM7, PR domain containing 10, PR/SET domain 10, RGD1560384, TRIS, tristanin
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PRDM10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Zinc finger, C2H2 type
  • zinc finger
  • transcription regulator
  • Zinc-finger double-stranded RNA-binding
  • Zinc-finger double domain
  • SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
  • SET domain
  • protein binding
  • Unstructured region on methyltransferase between zinc-fingers
  • transcription factor activity

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • neoplasia
  • dementia
  • Birt-Hogg-Dube syndrome type 2
  • fibrous tissue neoplasm
  • infection by HIV-1
regulated by
regulates
  • DNA endogenous promoter
  • DNA promoter
  • RNA polymerase II

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • nucleoplasm
  • chromatin

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human PRDM10 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • positive regulation of transcription, DNA-dependent
  • positive regulation of transcription from RNA polymerase II promoter
  • methylation

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • transcriptional repressor complex
  • chromatin

Molecular Function

What the gene product does at the molecular level
  • DNA binding
  • sequence-specific DNA binding transcription factor activity
  • protein binding
  • metal ion binding
  • methyltransferase activity

Gene-Specific Assays for Results You Can Trust

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