Myo15 Gene Summary [Mouse]
Predicted to enable actin filament binding activity and microfilament motor activity. Acts upstream of or within inner ear morphogenesis; locomotory behavior; and sensory perception of sound. Located in stereocilium. Is expressed in several structures, including brain; heart; inner ear; liver; and metanephros. Used to study autosomal recessive nonsyndromic deafness 3. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 3 and sensorineural hearing loss. Orthologous to human MYO15A (myosin XVA). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Myo15 |
| Official Name | myosin XV [Source:MGI Symbol;Acc:MGI:1261811] |
| Ensembl ID | ENSMUSG00000042678 |
| Bio databases IDs | |
| Aliases | myosin XV |
| Synonyms | AA516932, DFNB3, LOC102549801, MYO15, MYOSIN 15A, myosin XVA, RGD1561873, sh-2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Myo15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FERM central domain
- Band 4.1 homologues
- Calmodulin-binding motif
- Myosin and Kinesin motor domain
- protein binding
- Pleckstrin homology-like domain
- FERM domain B-lobe
- Myosin
- MyTH4 domain
- Myosin head (motor domain)
- Src Homology 3 domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hemorrhoid
- autosomal recessive deafness type 3
- ear malformation
- autosomal recessive deafness
- epithelial cancer
- Alzheimer disease
- hereditary disorder
- familial nonsyndromic hearing impairment
- autosomal recessive nonsyndromic hearing loss
- autosomal recessive deafness type 9
role in cell
- morphology
- length
- elongation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- stereocilia tip
- cytosol
- stereocilia
- nuclear scaffolds
- secretory granules
- filopodia
- filopodial tip
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Myo15 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sensory perception of sound
- locomotory behavior
- inner ear morphogenesis
- actin filament organization
- endocytosis
- response to light stimulus
Cellular Component
Where in the cell the gene product is active
- myosin complex
- extracellular vesicular exosome
- cytoplasm
- membrane
- actin cytoskeleton
- stereocilium
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- ATP binding
- calmodulin binding
- microfilament motor activity