P4hb Gene Summary [Mouse]
Enables integrin binding activity and protein-disulfide reductase activity. Involved in insulin processing. Acts upstream of with a positive effect on endoplasmic reticulum to Golgi vesicle-mediated transport. Acts upstream of or within cellular response to interleukin-7. Located in endoplasmic reticulum and external side of plasma membrane. Part of endoplasmic reticulum chaperone complex. Is active in endoplasmic reticulum lumen. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in Cole-Carpenter syndrome. Orthologous to human P4HB (prolyl 4-hydroxylase subunit beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | P4hb |
| Official Name | prolyl 4-hydroxylase, beta polypeptide [Source:MGI Symbol;Acc:MGI:97464] |
| Ensembl ID | ENSMUSG00000025130 |
| Bio databases IDs | |
| Aliases | prolyl 4-hydroxylase, beta polypeptide |
| Synonyms | CLCRP1, DSI, ERBA2L, ERp59, GIT, GLUTATHIONE INSULIN TRANSHYDROGENASE, P4Hbeta, PDI, Pdi1, Pdi2, PDIA1, PDIR, PHDB, PO4DB, PO4HB, PROHB, Prolyl 4-hydroxylase, prolyl 4-hydroxylase, beta polypeptide, prolyl 4-hydroxylase subunit beta, prolyl 4-hydroxylase subunit β, prolyl 4-hydroxylase, β polypeptide, protein DISULFIDE ISOMERASE, Thbp |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse P4hb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Calsequestrin
- protein disulfide-isomerase
- thiol oxidase
- thioredoxin-like domain
- protein disulfide oxidoreductase
- Thioredoxin-like
- enzyme binding
- linker domain
- enzyme
- protein binding
- thioredoxin
- procollagen-proline dioxygenase
- protein disulfide isomerase, eukaryotic
- binding protein
- b-type thioredoxin-like domain
- actin binding
- integrin binding
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- a-type thioredoxin-like domain
- protein disulfide-isomerase domain
- protein heterodimerization
Pathways
Biological processes and signaling networks where the P4hb gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- lung adenocarcinoma formation
- epithelial cancer
- hepatocellular carcinoma
- liver cancer
- renal clear cell adenocarcinoma
- colon epithelial cancer
- autoimmune pancreatitis
- colorectal cancer
- urothelial bladder carcinoma
role in cell
- proliferation
- production in
- activation in
- apoptosis
- expression in
- accumulation
- cell viability
- consumption in
- aggregation
- adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum fraction
- membrane fraction
- extracellular matrix fraction
- pH resistant lipid raft fraction
- endoplasmic reticulum mitochondria contact site
- cytoskeleton
- cell surface
- Nucleus
- Golgi Apparatus
- Endoplasmic Reticulum
- lipid droplets
- ER-to-Golgi intermediate compartment
- cytosol
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
- plasma membrane extracellular face
- basolateral membrane
- nucleoli
- nuclear rim
- rough endoplasmatic reticulum
- microsomal membrane
- phagosomes
- plasma
- lamellipodia
- phagocytic cups
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse P4hb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- insulin processing
- interleukin-23-mediated signaling pathway
- positive regulation of viral entry into host cell
- positive regulation of cell adhesion
- positive regulation of substrate adhesion-dependent cell spreading
- protein folding
- ER to Golgi vesicle-mediated transport
- cellular response to hypoxia
- peptidyl-proline hydroxylation to 4-hydroxy-L-proline
- response to endoplasmic reticulum stress
- protein folding in endoplasmic reticulum
- interleukin-12-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- endoplasmic reticulum
- endoplasmic reticulum-Golgi intermediate compartment
- extracellular region
- endoplasmic reticulum lumen
- extracellular vesicular exosome
- cytoskeleton
- focal adhesion
- melanosome
- cytosol
- macromolecular complex
- procollagen-proline 4-dioxygenase complex
- endoplasmic reticulum chaperone complex
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- procollagen-proline 4-dioxygenase activity
- RNA binding
- protein binding
- protein disulfide isomerase activity
- protein disulfide oxidoreductase activity
- actin binding
- protein heterodimerization activity
- integrin binding
- thiol oxidase activity
- enzyme binding