Dnali1 Gene Summary [Mouse]
Enables dynein heavy chain binding activity. Involved in sperm flagellum assembly. Located in several cellular components, including ciliary base; filopodium; and sperm flagellum. Is expressed in several structures, including brain ventricle and choroid plexus; choroid invagination; ependyma; epithelium; and testis. Human ortholog(s) of this gene implicated in spermatogenic failure 83. Orthologous to human DNALI1 (dynein axonemal light intermediate chain 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dnali1 |
| Official Name | dynein, axonemal, light intermediate polypeptide 1 [Source:MGI Symbol;Acc:MGI:1922813] |
| Ensembl ID | ENSMUSG00000042707 |
| Bio databases IDs | |
| Aliases | dynein, axonemal, light intermediate polypeptide 1 |
| Synonyms | 1700023A09RIK, dJ423B22.5, dynein axonemal light intermediate chain 1, dynein, axonemal, light intermediate chain 1, dynein, axonemal, light intermediate polypeptide 1, hp28, P28, SPGF83 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dnali1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Axonemal dynein light chain
- dynein heavy chain binding
Pathways
Biological processes and signaling networks where the Dnali1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- lung squamous cell carcinoma
- squamous cell lung cancer
- rectal adenocarcinoma
- colorectal carcinomagenesis
- rectum cancer
- chromophobe renal cell carcinoma
- chromophobe renal cancer
- spermatogenic failure 83
- hepatocellular carcinoma
role in cell
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- motile cilia
- microtubule cytoskeleton
- organelle
- cilia
- axonemes
- cytoplasmic bridges
- nucleoplasm
- sperm tail
- glial cell projections
- filopodia
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dnali1 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- motile cilium
- cytoplasm
- dynein complex
- cilium
- filopodium
- sperm flagellum
- axoneme
Molecular Function
What the gene product does at the molecular level
- protein binding
- dynein heavy chain binding