Tmtc1 Gene Summary [Mouse]
Predicted to enable dolichyl-phosphate-mannose-protein mannosyltransferase activity. Predicted to be involved in protein O-linked mannosylation. Located in mitochondrion. Is expressed in central nervous system; dorsal root ganglion; and forelimb bud. Orthologous to human TMTC1 (transmembrane O-mannosyltransferase targeting cadherins 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tmtc1 |
| Official Name | transmembrane and tetratricopeptide repeat containing 1 [Source:MGI Symbol;Acc:MGI:3039590] |
| Ensembl ID | ENSMUSG00000030306 |
| Bio databases IDs | |
| Aliases | transmembrane and tetratricopeptide repeat containing 1 |
| Synonyms | ARG99, OLF, RGD1564868, TMTC1A, transmembrane and tetratricopeptide repeat containing 1, transmembrane O-mannosyltransferase targeting cadherins 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tmtc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MalT-like TPR region
- TPR repeat
- Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family
- Protein O-mannosyl-transferase TMTC, DUF1736
- enzyme
- protein binding
- Assembly chaperone of ribosomal protein L4 and similar proteins
- Tetratricopeptide Repeats-Sensor
- tol-pal system protein YbgF
- Tetratricopeptide repeats
- type IV pilus biogenesis/stability protein PilW
- tetratricopeptide repeat
- dolichyl-phosphate-mannose-protein mannosyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- schizophrenia
- metastasis
- epithelial cancer
- ovarian cancer
- non-insulin-dependent diabetes mellitus
- epileptic seizure
- diabetic nephropathy
- androgenic alopecia
- organismal death
regulates
- mir-329 (includes others)
- MET
- Laminin (complex)
role in cell
- expression in
- apoptosis
- proliferation
- cell viability
- invasion by
- migration
- adhesion
- epithelial-mesenchymal transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tmtc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA processing
- protein O-linked mannosylation
Cellular Component
Where in the cell the gene product is active
- membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- mannosyltransferase activity
- dolichyl-phosphate-mannose-protein mannosyltransferase activity