Tbl1xr1 Gene Summary [Mouse]
Enables transcription cis-regulatory region binding activity and transcription corepressor activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including blastocyst hatching; fat pad development; and regulation of primary metabolic process. Predicted to be located in mitotic spindle and nucleus. Predicted to be part of histone deacetylase complex and transcription repressor complex. Is expressed in early conceptus; secondary oocyte; and thymus primordium. Used to study Pierpont syndrome. Human ortholog(s) of this gene implicated in Pierpont syndrome and autosomal dominant intellectual developmental disorder 41. Orthologous to human TBL1XR1 (TBL1X/Y related 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tbl1xr1 |
| Official Name | transducin (beta)-like 1X-linked receptor 1 [Source:MGI Symbol;Acc:MGI:2441730] |
| Ensembl ID | ENSMUSG00000027630 |
| Bio databases IDs | |
| Aliases | transducin (beta)-like 1X-linked receptor 1 |
| Synonyms | 8030499H02Rik, A630076E03Rik, C21, C230089I12Rik, DC42, IRA1, MRD41, RGD1560053, Tbl1xr1 predicted, TBL1X/Y related 1, TBLR1, TBLXR1, transducin (beta)-like 1X-linked receptor 1, transducin (β)-like 1X-linked receptor 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tbl1xr1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- transcription regulator
- Eukaryotic translation initiation factor eIF2A
- nucleic acid binding
- beta-catenin binding
- transcription co-repressor
- WD domain, G-beta repeat
- WD40
- protein binding
- sequence-specific DNA binding
- DNA binding
- Anaphase-promoting complex subunit 4 WD40 domain
- WD40 repeats
- double-stranded DNA binding
- Lissencephaly type1-like homology motif
- LisH
Pathways
Biological processes and signaling networks where the Tbl1xr1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gastric cancer
- neoplasia
- schizophrenia
- epilepsy
- asthma
- adult T-cell leukemia/lymphoma
- mature T-cell neoplasia
- T-cell non-Hodgkin disease
- intestinal gastric cancer
- B-cell non-Hodgkin disease
role in cell
- apoptosis
- phosphorylation in
- differentiation
- migration
- proliferation
- epithelial-mesenchymal transition
- invasion by
- binding in
- degradation in
- lipotoxicity in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- nucleoplasm
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tbl1xr1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organism growth
- positive regulation of canonical Wnt receptor signaling pathway
- fat pad development
- response to dietary excess
- positive regulation of transcription from RNA polymerase II promoter
- chromatin organization
- regulation of transcription from RNA polymerase II promoter
- white fat cell differentiation
- negative regulation of transcription from RNA polymerase II promoter
- proteasomal ubiquitin-dependent protein catabolic process
- positive regulation of transcription, DNA-dependent
- blastocyst hatching
- lipid catabolic process
- regulation of triglyceride metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitotic spindle
- transcriptional repressor complex
- histone deacetylase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- histone binding
- transcription corepressor activity
- transcription regulatory region sequence-specific DNA binding
- beta-catenin binding