Fgf11 Gene Summary [Mouse]
Predicted to enable sodium channel regulator activity. Predicted to be involved in neurogenesis. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human FGF11 (fibroblast growth factor 11). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fgf11 |
| Official Name | fibroblast growth factor 11 [Source:MGI Symbol;Acc:MGI:109167] |
| Ensembl ID | ENSMUSG00000042826 |
| Bio databases IDs | |
| Aliases | fibroblast growth factor 11 |
| Synonyms | Fgf1d, FHF-3, fibroblast growth factor 11 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fgf11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-trefoil_FGF
- fascin-like domain, beta-trefoil fold, found in the fascin-like family
- protein binding
- growth factor
Pathways
Biological processes and signaling networks where the Fgf11 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- mature T-cell neoplasia
- T-cell non-Hodgkin disease
- Moyamoya disease
- male pattern hair loss
- angioimmunoblastic T-cell lymphoma
- salivary gland mucoepidermoid carcinoma
- salivary gland cancer
- papillary thyroid carcinoma
- papillary thyroid cancer
regulates
- ERK1/2
- caspase 3/7
- Hbx
- NR1H4
role in cell
- growth
- expression in
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fgf11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- cell-cell signaling
- nervous system development
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- sodium channel regulator activity
- growth factor activity
- protein binding