Abra Gene Summary [Mouse]
Enables actin binding activity. Involved in actin cytoskeleton organization and positive regulation of Rho protein signal transduction. Acts upstream of or within positive regulation of transcription by RNA polymerase II and protein import into nucleus. Located in actin cytoskeleton and myofibril. Is expressed in embryo; heart; hindlimb muscle; and skeletal muscle. Orthologous to human ABRA (actin binding Rho activating protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Abra |
| Official Name | actin-binding Rho activating protein [Source:MGI Symbol;Acc:MGI:2444891] |
| Ensembl ID | ENSMUSG00000042895 |
| Bio databases IDs | |
| Aliases | actin-binding Rho activating protein |
| Synonyms | actin-binding Rho activating protein, C130068O12Rik, LOC107986900, Ms1, STARS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Abra often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin binding
- protein binding
- Costars
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- thoracic aortic aneurysms and dissections
role in cell
- polymerization
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- actin cytoskeleton
- Plasma Membrane
- sarcomere
- myofibrils
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Abra gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of Rho protein signal transduction
- protein import into nucleus
- transcription from RNA polymerase II promoter
- positive regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of transcription from RNA polymerase II promoter
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- actin cytoskeleton
- sarcomere
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- actin binding