Lrrfip1 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Acts upstream of or within positive regulation of NF-kappaB transcription factor activity. Predicted to be located in cytosol and plasma membrane. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and liver and biliary system. Orthologous to human LRRFIP1 (LRR binding FLII interacting protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lrrfip1 |
| Official Name | leucine rich repeat (in FLII) interacting protein 1 [Source:MGI Symbol;Acc:MGI:1342770] |
| Ensembl ID | ENSMUSG00000026305 |
| Bio databases IDs | |
| Aliases | leucine rich repeat (in FLII) interacting protein 1 |
| Synonyms | AU024550, FLAP-1, FLIIAP1, GCF-2, HUFI-1, leucine rich repeat (in FLII) interacting protein 1, LRR binding FLII interacting protein 1, TRIP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lrrfip1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lysine rich domain
- transcription regulator
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- DNA binding domain
- LRRFIP family
- double-stranded DNA binding
- nucleic acid binding
- double-stranded RNA binding
- protein homodimerization
- protein binding
- sequence-specific DNA binding
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- coronary artery disease
- self-abusive behavior
- breast cancer
- obesity
role in cell
- proliferation
- expression in
- production in
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- cytoskeleton
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lrrfip1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoskeleton
- cytoplasm
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein homodimerization activity
- protein binding
- double-stranded RNA binding
- cadherin binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity